当前位置：
X-MOL 学术
›
Environ. Sci. Technol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Potential Link between Equol Pollution and Field-Observed Intersex in Wild So-iuy Mullets (Mugil soiuy).
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2020-09-02 , DOI: 10.1021/acs.est.0c04083 Chen Wang 1, 2 , Lihui An 1, 2 , Shimin Wu 1 , Ai Jia 1 , Jianxian Sun 1 , Chong Huang 1 , Di Mu 1 , Jianying Hu 1
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2020-09-02 , DOI: 10.1021/acs.est.0c04083 Chen Wang 1, 2 , Lihui An 1, 2 , Shimin Wu 1 , Ai Jia 1 , Jianxian Sun 1 , Chong Huang 1 , Di Mu 1 , Jianying Hu 1
Affiliation
|
Gonadal intersex has been observed in wild fishes and is attributed to endocrine-disrupting chemicals but the specific causes remain controversial. Here, a forensic analysis utilizing field and laboratory studies was conducted to explore the causal agent(s). In a 2008–2009 survey of Liaodong Bay, China, 20.7–33.3% incidences of gonadal intersex were observed in male so-iuy mullets (Mugil soiuy), a wild sentinel fish species. Steroidal estrogen (estrone, 17β-estradiol, estriol, and ethinylestradiol) and phytoestrogen (equol) were detected in seawater where the fishes were collected with median concentrations of 0.42 ng/L (0.02–1.42 ng/L) E2 equivalent (EEQ-E2) and 22.81 ng/L (0.10–155.99 ng/L) equol. A probabilistic model was used to evaluate the ecological risk of these estrogenic chemicals based on their distribution in the field and dose–response relationship from the laboratory surrogate Japanese medaka (Oryzias latipes) fish. The probability of the incidences of gonadal intersex due to equol exposure was estimated to be 13.5 ± 12.1%, which is considerably higher than that for EEQ-E2, (7.2 ± 68.8) × 10–4. The agonistic activity of equol to the estrogen receptor α of so-iuy mullets was 3.5-fold higher than that to the estrogen receptor α of Japanese medaka, indicating that equol shows a stronger potential for inducing intersex in so-iuy mullets than in medaka. These results demonstrate that equol, rather than steroid estrogens, is a more likely causal agent for the field-observed intersex in male wild so-iuy mullets.
更新日期：2020-10-06
京公网安备 11010802027423号